Acetic Acid → HCID 117803008, compound

Participants

Reaction Steps

A solution of 160g (10 g, 22 mmol) in acetic acid (100 mL) was stirred at 120° C. for 5 h. See FIG. 5. The mixture was concentrated under reduced pressure, and the residue was purified by column chromatography on silica gel (eluting with petroleum ether:ethyl acetate=3:1) to afford (2-(6-(tert-butyl)-1H-benzo[d]imidazol-2-yl)-4-chloropyridin-3-yl)methyl acetate 160h (3.5 g, 44%) as a yellow solid. MS-ESI: [M+H]+ 358.2.

Provenance & Evidence