Acetic Anhydride → HCID 19963170, compound

HRID 52035Notes

Reaction equation

HRID 52035 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][N:6]=[C:5]2[NH:12][C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([Cl:19])[CH:14]=1.[C:20](OC(=O)C)(=[O:22])[CH3:21]>>[C:20]([NH:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][N:6]=[C:5]2[NH:12][C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([Cl:19])[CH:14]=1)(=[O:22])[CH3:21]

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 11807783N4-(3-chlorophenyl)quinazoline-4,6-diamine

Product 1

HCID 19963170HCID 19963170, compoundYield 50%

Procedure

Using an analogous procedure to that described in Example 11, 6-amino-4-(3'-chloroanilino)quinazoline was reacted with acetic anhydride to give 6-acetamido-4-(3'-chloroanilino)quinazoline in 50% yield, m.p. 260°-262° C.

Sources & evidence

ORD record
ord-05cf0cd5183c4b93b3d1352cdb1372fe
Source dataset
uspto-grants-1997_04
Patent number
US05616582

Reaction notes

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