Methoxyacetyl chloride → 6-(2-Methoxyacetamido)-4-(3'-chloroanilino)quinazoline

Beteiligte Stoffe

Reaktionsschritte

Using an analogous procedure to that described in Example 13 except that the reaction mixture was stirred at ambient temperature rather than being heated to 100° C., 6-amino-4-(3'-chloroanilino)quinazoline was reacted with 2-methoxyacetyl chloride to give 6-(2-methoxyacetamido)-4-(3'-chloroanilino)quinazoline in 41% yield, m.p. 177°-180° C.

Herkunft & Nachweise