HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,4-Dioxane hydrochloride → (S)-ethyl 2-amino-4-fluoro-3,3-dimethylbutanoate HCl
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,4-Dioxane hydrochloride | HCID 20443148 | — |
| Reactant | (S)-ethyl 2-((S)-1,1-dimethylethylsulfinamido)-4-fluoro-3,3-dimethylbutanoate | HCID 86690080 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | (S)-ethyl 2-amino-4-fluoro-3,3-dimethylbutanoate HCl | HCID 86690081 | 100.5% |
Reaction Steps
To a solution of (S)-ethyl 2-((S)-1,1-dimethylethylsulfinamido)-4-fluoro-3,3-dimethylbutanoate (0.38 g, 1.350 mmol) in MeOH (10 mL) was added HCl/dioxane (1.350 mL, 5.40 mmol). The reaction mixture was stirred at rt for 30 min and concentrated to afford (S)-ethyl 2-amino-4-fluoro-3,3-dimethylbutanoate/HCl as a white solid (0.29 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09326973B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-dca3387010364996ab7fc060d28b598f |
| Source note | uspto-grants-2016_05 |