Spiro[3.3]heptane-2-carboxylic acid, 6,6-difluoro-, phenylmethyl ester → 6,6-Difluoro-spiro[3.3]heptane-2-carboxylic acid

Participants

Reaction Steps

A stirred suspension of 10% Pd—C (40.6 mg) in an EtOAc (10 mL) solution of benzyl 6,6-difluorospiro[3.3]heptane-2-carboxylate (203 mg) was hydrogenated under balloon pressure for 2 h. The suspension was filtered and the filtrate was evaporated to dryness to afford Cap-13 as a clear viscous oil. 1H NMR (400 MHz, CHLOROFORM-d) δ 3.18-3.08 (m, 1H), 2.69-2.55 (m, 4H), 2.52-2.37 (m, 4H).

Provenance & Evidence