HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 52042Generated: October 29, 2026
1,2-Dibromoethane → 6-(2-Bromoethoxy)-4-(3'-methylanilino)quinazoline
https://huagongshe.com/reaction/52042
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1,2-Dibromoethane | HCID 7839 | — |
| Reactant | 6-Hydroxy-4-(3'-methylanilino)quinazoline | HCID 19963207 | — |
| Solvent | Dimethylacetamide | HCID 31374 | — |
| Product | 6-(2-Bromoethoxy)-4-(3'-methylanilino)quinazoline | HCID 19963138 | 47% |
Reaction Steps
Using an analogous procedure to that described in Example 39, except that DMA was used in place of DMF and that the reaction mixture was heated to 80° C. for 4 hours, 6-hydroxy-4-(3'-methylanilino)quinazoline was reacted with 1,2-dibromoethane to give 6-(2-bromoethoxy)-4-(3'-methylanilino)quinazoline in 47% yield, m.p. 129°-135° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05616582 |
|---|
| Source dataset | uspto-grants-1997_04 |
|---|
| ORD ID | ord-930a70d401ed49c78d587729df046742 |
|---|
| Source note | uspto-grants-1997_04 |
|---|
