m-Toluidine → HCID 19963135, compound

HRID 52043Notes

Reaction equation

HRID 52043 reaction equation
[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([N:12]3[CH2:17][CH2:16][O:15][CH2:14][CH2:13]3)[CH:10]=2)[N:5]=[CH:4][N:3]=1.[CH3:18][C:19]1[CH:20]=[C:21]([CH:23]=[CH:24][CH:25]=1)[NH2:22]>>[ClH:1].[CH3:18][C:19]1[CH:20]=[C:21]([CH:23]=[CH:24][CH:25]=1)[NH:22][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([N:12]3[CH2:17][CH2:16][O:15][CH2:14][CH2:13]3)[CH:10]=2)[N:5]=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 7934m-ToluidineHCID 21717193153437-50-4

Product 1

HCID 19963135HCID 19963135, compoundYield 76%

Procedure

Using an analogous procedure to that described in Example 1, 4-chloro-6-morpholinoquinazoline was reacted with 3-methylaniline to give 4-(3'-methylanilino)-6-morpholinoquinazoline hydrochloride in 76% yield, m.p. 276°-278° C.

Sources & evidence

ORD record
ord-11361a29aa8f42f3b167e7d481578e96
Source dataset
uspto-grants-1997_04
Patent number
US05616582

Reaction notes

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