反应详情

温度

80 °C

Pyridine-3-sulfonyl chloride hydrochloride 7 (280 mg, 1.3 mmol) was added to a solution of 8-amino-3-methyl-2-(3-(trifluoromethyl)phenyl)quinazolin-4(3H)-one 5 (100 mg, 0.313 mmol) in pyridine (5 mL). The reaction mixture was heated at 80° C. for 12 h. The pyridine was removed in vacuo. The residue was taken up in CH2Cl2, washed with sat. aq NaHCO3, dried (MgSO4) and concentrated. The crude residue was purified by MPLC eluting with CH2Cl2/MeOH (0-10%) followed by recrystallization from CH3CN to give Compound 361 (77 mg, 53% yield). MS (ESI) calcd for C21H15F3N4O3S: 460.08. found: 461 [M+H].

1. customThe pyridine was removed in vacuo
2. washwashed with sat. aq NaHCO3
3. dry with materialdried (MgSO4)
4. concentrationconcentrated
5. customThe crude residue was purified by MPLC
6. washeluting with CH2Cl2/MeOH (0-10%)
7. customfollowed by recrystallization from CH3CN