HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 520442Generated: October 29, 2026
2-Pyrazinecarboxylic acid → HCID 136359923, compound
https://huagongshe.com/reaction/520442
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Pyrazinecarboxylic acid | HCID 1047 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 136127578 | HCID 136127578 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylacetamide | HCID 31374 | — |
| Product | HCID 136359923 | HCID 136359923 | 86% |
Reaction Steps
A mixture of 8-amino-2-(3-(trifluoromethyl)phenyl)quinazolin-4(3H)-one 9 (125 mg, 0.41 mmol), pyrazine-2-carboxylic acid 10 (102 mg, 0.82 mmol), HATU (342 mg, 0.90 mmo) and DIPEA (214 μl, 1.2 mmol) in DMAC (5 mL) were heated at 70° C. for 12 h then poured into H2O. The precipitate was collected by filtration, rinsed with H2O then recrystallized from EtOH to give Compound 231 (144 mg, 86% yield) as a white solid. MS (ESI) calc. for C20H12F3N5O2: 411.09. found: 412 [M+H].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09326986B2 |
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| Source dataset | uspto-grants-2016_05 |
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| ORD ID | ord-c75740068de84870a1c5b7700c77b4c4 |
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| Source note | uspto-grants-2016_05 |
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