HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-[Bis[(tert-butyloxy)carbonyl]amino]-3-nitrobenzoic Acid Methyl Ester → Methyl 3-amino-2-(bis(tert-butoxycarbonyl)amino)benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-[Bis[(tert-butyloxy)carbonyl]amino]-3-nitrobenzoic Acid Methyl Ester | HCID 11372853 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Methyl 3-amino-2-(bis(tert-butoxycarbonyl)amino)benzoate | HCID 58552839 | 80% |
Reaction Steps
Raney Ni (1 g) was added to a solution of methyl 2-(bis-(tert-butoxycarbonyl)amino)-3-nitrobenzoate 12 (6 g, 27.5 mmol) in THF. The reaction mixture was hydrogenated under balloon pressure for 4 h. The catalyst was removed by filtration and the solvent evaporated to give 13 (4.4 g, 80% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09326986B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-2fc75285a5d64b158ab1ce23b6b541ce |
| Source note | uspto-grants-2016_05 |