HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Anhydride → 8-Nitro-2-(3-(trifluoromethyl)phenyl)quinolin-4-yl acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 8-nitro-2-(3-(trifluoromethyl)phenyl)quinolin-4(1H)-one | HCID 58552922 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 8-Nitro-2-(3-(trifluoromethyl)phenyl)quinolin-4-yl acetate | HCID 58552856 | — |
Reaction Steps
A solution of 8-nitro-2-(3-(trifluoromethyl)phenyl)quinolin-4(1H)-one 37 (707 mg, 2.11 mmol), triethylamine (1 mL), and Ac2O (0.7 mL) in CH2Cl2 (10 mL) was stirred at room temperature for 16 h. Sat. aq NaHCO3 (10 mL) was added, and the reaction extracted with CH2Cl2. The combined organic layers were dried (MgSO4) and concentrated to give 38.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09326986B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-a2d89c3bf66c4a74b48425fa29bee2a5 |
| Source note | uspto-grants-2016_05 |