HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 520479Generated: October 29, 2026
Hydrochloric Acid → 6-(Pyrrolidin-1-ylmethyl)picolinic acid
https://huagongshe.com/reaction/520479
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | HCID 15123266 | HCID 15123266 | — |
| Solvent | Water ethanol | HCID 19096565 | — |
| Product | 6-(Pyrrolidin-1-ylmethyl)picolinic acid | HCID 46318234 | 80.1% |
Reaction Steps
A mixture of methyl 6-(pyrrolidin-1-ylmethyl)picolinate 69 (36 g) and NaOH (40 g, 1.0 mol) in ethanol/H2O (320 mL) was stirred at 75° C. for 16 h. The pH was adjusted to 7 with 3N HCl and extracted with EtOAc. The aqueous layer was concentrated to dryness and extracted with dichloromethane/methanol (v:v=3:1), The organic layer was dried to give 70 (27 g, 55% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09326986B2 |
|---|
| Source dataset | uspto-grants-2016_05 |
|---|
| ORD ID | ord-83c4013480dc42a6ba1df8162ce93c75 |
|---|
| Source note | uspto-grants-2016_05 |
|---|
