1-Mercapto-2-propanol → HCID 67725881, compound

HRID 52050Notes

Reaction equation

HRID 52050 reaction equation
[N:1]1([CH2:7][C:8]2[CH:13]=[CH:12][N:11]=[C:10]([O:14][CH2:15]/[CH:16]=[CH:17]\[CH2:18][NH:19][C:20](=[O:23])[CH2:21]Cl)[CH:9]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[SH:24][CH2:25][CH:26]([OH:28])[CH3:27]>>[N:1]1([CH2:7][C:8]2[CH:13]=[CH:12][N:11]=[C:10]([O:14][CH2:15]/[CH:16]=[CH:17]\[CH2:18][NH:19][C:20](=[O:23])[CH2:21][S:24][CH2:25][CH:26]([OH:28])[CH3:27])[CH:9]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 1025451-Mercapto-2-propanolHCID 67725626N-[4-(4-Piperidinomethyl-2-pyridyloxy)-cis-2-butenyl]-2-chloroacetamide

Product 1

HCID 67725881HCID 67725881, compoundYield 89%

Procedure

Following a procedure similar to that described in Example 1, but using N-[4-(4-piperidinomethyl-2-pyridyloxy) -cis-2-butenyl]-2-chloroacetamide (prepared as described in Preparation 1) and 1-mercapto-2-propanol as starting materials, in relative proportions similar to those used in that Example, the title compound was obtained in an 89% yield.

Sources & evidence

ORD record
ord-dd8e587b9448460a96c9b6f7fe73ca5b
Source dataset
uspto-grants-1997_04
Patent number
US05616579

Reaction notes

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