反应详情

温度

130 °C

A stirred mixture of 6-Bromo-1-[(4-methylphenyl)sulphonyl]-4-(1H-tetrazol-5-yl)-1H-indazole (300 mg, 0.615 mmol) and acetyl chloride (0.722 ml, 10.15 mmol) in toluene (10 ml) were heated under microwave irradiation at 130° C. for 20 mins. The reaction mixture was heated for a further 20 mins at 130° C. then evaporated to dryness. The resultant yellow solid was treated with methanol (10 ml), to give a beige solid and supernatant. The supernatant was pipetted off, the process repeated twice and the resultant solid dried under vacuum to give the title compound as a beige solid (75 mg).

1. temperatureThe reaction mixture was heated for a further 20 mins at 130° C.
2. customthen evaporated to dryness
3. additionThe resultant yellow solid was treated with methanol (10 ml)
4. customto give a beige solid
5. customthe resultant solid dried under vacuum