HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 6-Oxa-9-azaspiro(4.5)decane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 9-Boc-6-oxa-9-azaspiro[4.5]decane | HCID 1514339 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 6-Oxa-9-azaspiro(4.5)decane | HCID 22417172 | 173.4% |
Reaction Steps
To a of solution 1,1-dimethylethyl 6-oxa-9-azaspiro[4.5]decane-9-carboxylate (200 mg, 0.829 mmol, available from Tyger Scientific Inc) in DCM (3 ml) was added trifluoroacetic acid (TFA) (0.5 ml). The resulting colourless yellow solution was stirred at room temperature for 24 hr. The solvent was evaporated to give the title compound as a grey oil (203 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09326987B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-3c162852ea0642de9223ca168f21b6b1 |
| Source note | uspto-grants-2016_05 |