HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 520586Generated: October 29, 2026
Water → 6-(Chloromethyl)-N-[6-(1H-indol-4-yl)-1-(phenylsulfonyl)-1H-indazol-4-yl]-2-pyridinecarboxamide
https://huagongshe.com/reaction/520586
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 6-(1H-indol-4-yl)-1-(phenylsulfonyl)-1H-indazol-4-amine | HCID 58268018 | — |
| Reactant | 6-(Chloromethyl)-2-pyridinecarbonyl chloride | HCID 86653302 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | 6-(Chloromethyl)-N-[6-(1H-indol-4-yl)-1-(phenylsulfonyl)-1H-indazol-4-yl]-2-pyridinecarboxamide | HCID 58267986 | — |
Reaction Steps
To solution of 6-(1H-indol-4-yl)-1-(phenylsulfonyl)-1H-indazol-4-amine (1.37 g) in chloroform (30 ml) at 0° C. was added DIPEA (1.232 ml). 6-(Chloromethyl)-2-pyridinecarbonyl chloride (1.519 g, crude) in chloroform (15 ml) was added dropwise and the mixture was stirred at 0° C. for 15 min. Water (30 ml) was added and the mixture was extracted with DCM (50 ml), separating the layers by hydrophobic frit.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09326987B2 |
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| Source dataset | uspto-grants-2016_05 |
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| ORD ID | ord-67681d003e40489a9c6417ba59fa386b |
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| Source note | uspto-grants-2016_05 |
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