HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 520587Generated: October 28, 2026
1-(phenylsulfonyl)-6-(trimethylstannanyl)-1H-indazol-4-amine → 6-(6-Fluoro-1-((4-nitrophenyl)sulfonyl)-1H-indol-4-yl)-1-(phenylsulfonyl)-1H-indazol-4-amine
https://huagongshe.com/reaction/520587
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1-(phenylsulfonyl)-6-(trimethylstannanyl)-1H-indazol-4-amine | HCID 58255743 | — |
| Reactant | 4-Bromo-6-fluoro-1-[(4-nitrophenyl)sulfonyl]-1H-indole | HCID 58356370 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 6-(6-Fluoro-1-((4-nitrophenyl)sulfonyl)-1H-indol-4-yl)-1-(phenylsulfonyl)-1H-indazol-4-amine | HCID 67227592 | — |
Reaction Steps
A mixture of 1-(phenylsulfonyl)-6-(trimethylstannanyl)-1H-indazol-4-amine (0.8 g), 4-bromo-6-fluoro-1-[(4-nitrophenyl)sulfonyl]-1H-indole (0.879 g) and Pd(PPh3)4 (0.212 g) in DMF (5 ml) was heated at 120° C. for 18 h. The solvent was removed in vacuo and the residue purified by silica cartridge (100 g) using a gradient of cyclohexane and ethyl acetate to give the title compound as an orange solid, 0.42 g.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09326987B2 |
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| Source dataset | uspto-grants-2016_05 |
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| ORD ID | ord-546c6295f29749c88c0feaeba61a9591 |
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| Source note | uspto-grants-2016_05 |
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