HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → 2-Methyl-N-(1-methyl-6-{1-[(4-methylphenyl)sulfonyl]-1H-pyrrolo[2,3-b]pyridin-4-yl}-1H-indazol-4-yl)-1,3-thiazole-4-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | 2-Methyl-1,3-thiazole-4-carbonyl chloride | HCID 21183959 | — |
| Reactant | HCID 66692086 | HCID 66692086 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-Methyl-N-(1-methyl-6-{1-[(4-methylphenyl)sulfonyl]-1H-pyrrolo[2,3-b]pyridin-4-yl}-1H-indazol-4-yl)-1,3-thiazole-4-carboxamide | HCID 66692383 | — |
Reaction Steps
1-Methyl-6-{1-[(4-methylphenyl)sulfonyl]-1H-pyrrolo[2,3-b]pyridin-4-yl}-1H-indazol-4-amine (75 mg) and pyridine (0.029 ml) were added to DCM (5 ml) under stirring at RT under nitrogen. 2-Methyl-1,3-thiazole-4-carbonyl chloride (38 mg) was added into the reaction mixture. The reaction mixture was partitioned between water (20 ml) and DCM (20 ml).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09326987B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-589937ff85e14ad899a718ce3035ca44 |
| Source note | uspto-grants-2016_05 |