HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Nitrobenzenesulfonyl chloride → 4-Bromo-1-[(4-nitrophenyl)sulfonyl]-1H-indole-6-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Nitrobenzenesulfonyl chloride | HCID 7404 | — |
| Reactant | 2-((1,1-Dimethylethyl)imino)-N,N-diethylhexahydro-1,3-dimethyl-2lambda5-1,3,2-diazaphosphorin-2-amine | HCID 3513851 | — |
| Reactant | 4-bromo-1H-indole-6-carbonitrile | HCID 24728883 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-Bromo-1-[(4-nitrophenyl)sulfonyl]-1H-indole-6-carbonitrile | HCID 66692272 | — |
Reaction Steps
4-Bromo-1H-indole-6-carbonitrile (207 mg), PS-BEMP (900 mg) and 4-nitrobenzenesulfonyl chloride (380 mg) were weighed to a round bottom flask, then N,N-Dimethylformamide (4 ml) was added and the reaction was stirred at RT. The reaction was filtered and washed with DMF. The DMF was evaporated and the residue was dissolved in DCM:methanol and passed through a 5 g SAX cartridge (preconditioned with methanol) washing with DCM:methanol. The residue was evaporated to afford the title compound, 360 mg as a pale orange solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09326987B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-b012c838402e4d64b66e3aab0f2606b9 |
| Source note | uspto-grants-2016_05 |