HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 520599Generated: October 30, 2026
Hydrochloric Acid → 4-bromo-2-chloro-1H-indole
https://huagongshe.com/reaction/520599
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 4-Bromo-2-chloro-1-[(4-methylphenyl)sulfonyl]-1H-indole | HCID 68226494 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 4-bromo-2-chloro-1H-indole | HCID 19700309 | — |
Reaction Steps
4-Bromo-2-chloro-1-[(4-methylphenyl)sulfonyl]-1H-indole (215 mg), IPA (2.5 ml) and 2 M NaOH (aq) (2.5 ml) were mixed in a microwave vial and heated in the microwave for 30 min at 120° C. The reaction was acidified using 2M HCl (aq) and then extracted with DCM, which was passed through a hydrophobic frit, then evaporated to dryness. The residue was triturated with methanol which was then evaporated to afford the title compound, 112 mg.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09326987B2 |
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| Source dataset | uspto-grants-2016_05 |
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| ORD ID | ord-d646c431cbbf481e812a3bc780829b0b |
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| Source note | uspto-grants-2016_05 |
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