HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,3,5-trimethyl-1H-pyrazole-4-carboxylic acid → 1,3,5-Trimethyl-N-[4-(4-piperidinomethyl-2-pyridyloxy)-cis-2-butenyl]pyrazole-4-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,3,5-trimethyl-1H-pyrazole-4-carboxylic acid | HCID 736514 | — |
| Reactant | 2-Buten-1-amine, 4-[[4-(1-piperidinylmethyl)-2-pyridinyl]oxy]-, (Z)- | HCID 13672473 | — |
| Product | 1,3,5-Trimethyl-N-[4-(4-piperidinomethyl-2-pyridyloxy)-cis-2-butenyl]pyrazole-4-carboxamide | HCID 67725941 | 69% |
Reaction Steps
Following a procedure similar to that described in Example 13, but using 4-(4-piperidinomethyl-2-pyridyloxy) -cis-2-butenylamine and 1,3,5-trimethyl-4-pyrazolecarboxylic acid as starting materials, in relative proportions similar to those used in that Example, the title compound was obtained as a white powder, melting at 75°-77° C., in a 69% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05616579 |
| Source dataset | uspto-grants-1997_04 |
| ORD ID | ord-97634292eed04e4eaaf1d549f2eb5695 |
| Source note | uspto-grants-1997_04 |