HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ibuprofen, (+-)- → Methyl (alphaR)-alpha-methyl-4-(2-methylpropyl)benzeneacetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ibuprofen, (+-)- | HCID 3672 | — |
| Reactant | Diazomethane | HCID 9550 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | Methyl (alphaR)-alpha-methyl-4-(2-methylpropyl)benzeneacetate | HCID 5326009 | — |
Reaction Steps
A solution of (R) (−)-ibuprofen (3.45 g) in ethyl ether, cooled to 5° C., is treated, dropwise, with a 0.6 M solution of diazomethane in ethyl ether, up to a persistent yellow colour. The solvent is removed—under vacuum; the residual oil is purified by flash chromatography to yield 3.3 g of methyl (R) (−) 2-(4′-isobutylphenyl)-propionate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09328057B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-3607a45b4a0f40ecb05b7f23a4f0285f |
| Source note | uspto-grants-2016_05 |