反应详情

Next, 20 mL of ethylenediamine was added to 2.0 g (12.4 mmol) of 2-chloro-5-chloromethylpyridine, and the mixture was stirred overnight. Following reaction completion, the reaction mixture was concentrated under reduced pressure, after which acetonitrile was added and insoluble matter were removed by filtration. The filtrate was concentrated under reduced pressure, giving 2.45 g (yield, 100%) of N-((6-chloropyridin-3-yl)methyl)ethane-1,2-diamine.

1. customreaction completion
2. concentrationthe reaction mixture was concentrated under reduced pressure
3. additionafter which acetonitrile was added
4. custominsoluble matter were removed by filtration
5. concentrationThe filtrate was concentrated under reduced pressure