2-(Isobutyl)quinoxaline → HCID 73507582, compound

Participants

Reaction Conditions

Reaction Steps

To an argon-purged pressure-resistant glass vessel (100 mL) equipped with a magnetic stir bar, RuCl[(R)-daipena][(R)-dm-segphos] (2.4 mg, 2.0 μmol) and KO(t-Bu) (11.9 mg, 0.106 mmol) were added, and the vessel was purged with argon again. To this vessel, a toluene (2.0 mL) solution containing 2-isobutylquinoxaline (378.3 mg, 2.03 mmol) and being degassed by the freeze-pump-thaw technique in advance was added by pressure transfer using a cannula. An operation in which hydrogen was introduced into the pressure-resistant vessel up to 0.8 MPa and then released was repeated 10 times to completely substitute the inside with hydrogen. Then, hydrogen was introduced up to 2.0 MPa, and the vessel was stirred in a water bath at 40° C. for 31 hours. After hydrogen was released, the solution was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (hexane:ethyl acetate=7:1 to 4:1 to 1:1) to obtain (S)-1,2,3,4-tetrahydro-2-isobutylquinoxaline (316.4 mg, 82%). A result of an analysis was conducted by high performance liquid chromatography (column: CHIRALCEL OD-H, mobile phase: hexane:IPA=80:20, 1 mL/min) showed that the optical purity of this product was 97% ee.

Provenance & Evidence