6-Chloro-2-methylquinoxaline → HCID 44596388, compound

HRID 520781Notes

Reaction equation

HRID 520781 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([CH3:12])[CH:6]=[N:5]2>C1(C)C=CC=CC=1>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[NH:8][C@@H:7]([CH3:12])[CH2:6][NH:5]2

Participants

3

Reactant 1

HCID 2897276-Chloro-2-methylquinoxaline

Product 1

HCID 44596388HCID 44596388, compoundYield 97.3%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Conditions

Temperature
40 °C

Procedure

To an argon-purged pressure-resistant glass vessel (100 mL) equipped with a magnetic stir bar, RuCl[(R)-daipena][(R)-dm-segphos] (1.1 mg, 0.94 μmol) and KO(t-Bu) (5.3 mg, 0.047 mmol) were added, and the vessel was purged with argon again. To this vessel, a toluene (2.5 mL) solution containing 6-chloro-2-methylquinoxaline (33.6 mg, 0.188 mmol) and being degassed by the freeze-pump-thaw technique in advance was added by pressure transfer using a cannula. An operation in which hydrogen was introduced into the pressure-resistant vessel up to 0.8 MPa and then released was repeated 10 times to completely substitute the inside with hydrogen. Then, hydrogen was introduced up to 2.0 MPa, and the vessel was stirred in a water bath at 40° C. for 16 hours. After hydrogen was released, the solution was concentrated under reduced pressure, and the residue was purified through a silica gel short path column (dichloromethane) to obtain (S)-6-chloro-1,2,3,4-tetrahydro-2-methylquinoxaline (33.4 mg, 97%). A result of an analysis was conducted by high performance liquid chromatography (column: CHIRALCEL OD-H, mobile phase: hexane:IPA=90:10, 1 mL/min) showed that the optical purity of this product was 99% ee or higher.

Workup

  1. customTo an argon-purged pressure-resistant glass vessel (100 mL)
  2. customequipped with a magnetic stir bar
  3. customthe vessel was purged with argon again
  4. custombeing degassed by the freeze-pump-thaw technique in advance
  5. additionwas added by pressure transfer
  6. additionAn operation in which hydrogen was introduced into the pressure-resistant vessel up to 0.8 MPa
  7. additionThen, hydrogen was introduced up to 2.0 MPa
  8. concentrationthe solution was concentrated under reduced pressure
  9. customthe residue was purified through a silica gel short path column (dichloromethane)

Sources & evidence

ORD record
ord-58ac38db51cd4bb7a50ccd6a918f051c
Source dataset
uspto-grants-2016_05
Patent number
US09328079B2

Reaction notes

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