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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 52079Generated: October 26, 2026

N-[4-(4-piperidinomethyl-2-pyridyloxy)-cis-2-butenyl]-4-chlorobutyramide → N-[4-(4-Piperidinomethyl-2-pyridyloxy)-cis-2-butenyl]-4-(5-methyl-1,3,4-oxadiazol-2-ylthio)butyramide

https://huagongshe.com/reaction/52079

Reaction equation

Participants

RoleNameHCIDCharge
ReactantN-[4-(4-piperidinomethyl-2-pyridyloxy)-cis-2-butenyl]-4-chlorobutyramideHCID 67726214—
ReactantHCID 178434159HCID 178434159—
ProductN-[4-(4-Piperidinomethyl-2-pyridyloxy)-cis-2-butenyl]-4-(5-methyl-1,3,4-oxadiazol-2-ylthio)butyramideHCID 6772602779%

Reaction Steps

Following a procedure similar to that described in Example 34, but using N-[4-(4-piperidinomethyl-2-pyridyloxy) -cis-2-butenyl]-4-chlorobutyramide (prepared as described in Preparation 2) and 2-mercapto-5-methyl -1,3,4-oxadiazole as starting materials, in relative proportions similar to those used in that Example, the title compound was obtained as an oil in a 79% yield.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05616579
Source datasetuspto-grants-1997_04
ORD IDord-7633f3908fbb4e1ba9da02e80d9bc1d6
Source noteuspto-grants-1997_04