Benzene, 2-ethynyl-1,4-difluoro- → HCID 72710860, compound

HRID 520797Notes

Reaction equation

HRID 520797 reaction equation
I[C:2]1[CH:3]=[CH:4][C:5]([N:8]2[C:12](=[O:13])[CH2:11][C@H:10]3[CH2:14][CH2:15][CH2:16][C@@H:9]23)=[N:6][CH:7]=1.[C:17]([C:19]1[CH:24]=[C:23]([F:25])[CH:22]=[CH:21][C:20]=1[F:26])#[CH:18]>>[F:26][C:20]1[CH:21]=[CH:22][C:23]([F:25])=[CH:24][C:19]=1[C:17]#[C:18][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[C:12](=[O:13])[CH2:11][C@H:10]3[CH2:14][CH2:15][CH2:16][C@@H:9]23)=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 50998805Benzene, 2-ethynyl-1,4-difluoro-HCID 90031855HCID 90031855, compound

Product 1

HCID 72710860HCID 72710860, compoundYield 98%

Procedure

The title compound was prepared in accordance with the general method of Example 1, step 7 using (3aR,6aR)-1-(5-iodopyridin-2-yl)hexahydro-cyclopenta[b]pyrrol-2(1H)-one (140 mg, 0.427 mmol) (Example 1, step 6) and 1-ethynyl-2,5-difluorobenzene to yield 142 mg (98%) of the title compound as a viscous light brown oil; MS: m/e=339.5 (M+H+).

Sources & evidence

ORD record
ord-2d55f2ebc27146e7af56471d2a7cddce
Source dataset
uspto-grants-2016_05
Patent number
US09328090B2

Reaction notes

Loading…