反应详情

A mixture of phenethyl alcohol (20 g), 1,6-dibromohexane (195 g) and tetrabutylammonium bisulphate (3.0 g) in 50% w/v NaOH solution (100 ml) was heated at 65-70° for 4h. The cooled reaction mixture was poured into H2O (400 ml) and extracted with CX (2×300 ml). The dried extracts were evaporated in vacuo to give a yellow liquid which was purified by distillation under reduced pressure to give the title compound as a colourless liquid (26 g) b.p. 110°/0.1 mm. T.l.c. (EA) Rf 0.62.

1. temperaturewas heated at 65-70° for 4h
2. customThe cooled reaction mixture
3. extractionextracted with CX (2×300 ml)
4. customThe dried extracts were evaporated in vacuo
5. customto give a yellow liquid which
6. distillationwas purified by distillation under reduced pressure