HuagongsheHuagongshe Chemistry Print Report · For research reference only
Malonic Acid → 3-[4-(1-t-Butyloxycarbonyl piperidin-4-yloxy)phenyl]prop-2-ene-1-oic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Malonic Acid | HCID 867 | — |
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | tert-Butyl 4-(4-formylphenoxy)piperidine-1-carboxylate | HCID 22632605 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 3-[4-(1-t-Butyloxycarbonyl piperidin-4-yloxy)phenyl]prop-2-ene-1-oic acid | HCID 90042113 | — |
Reaction Steps
A solution of t-Butyl 4-(4-formyl phenoxy)piperidine-1-carboxylate (50.2 grams, 0.164 moles, obtained in above step), malonic acid (50.6 grams, 0.486 moles) and piperidine (12.5 mL) in pyridine (250 mL) was stirred for 8 hours at 110° C. under nitrogen atmosphere.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09328092B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-20138aec10724831b047a0919b58f274 |
| Source note | uspto-grants-2016_05 |