反应详情

To a stirred solution of 3-[4-(1-Cyclobutyl piperidin-4-yloxy)phenyl]-1-(morpholin-4-yl)prop-2-ene-1-one (23.52 grams, 0.063 moles) in methanol (300 mL) was added a solution of fumaric acid (7.32 grams, 0.063 moles) in 30 mL methanol. The clear mass, thus obtained, was further stirred for 2-3 hours at room temperature. The solvent was evaporated to afford a solid mass. The solid mass was triturated with diethyl ether (3×100 mL) and dried under reduced pressure to obtain the title compound (29.54 grams).

1. customThe clear mass, thus obtained
2. customThe solvent was evaporated
3. customto afford a solid mass
4. customThe solid mass was triturated with diethyl ether (3×100 mL)
5. customdried under reduced pressure