反应详情

A heterogenous mixture of (1-methyl-1H-imidazol-5-yl)(pyridin-2-yl)methanol (1.41 g, 7.45 mmol, Intermediate 6: step a) and manganese dioxide (3.24 g, 37.27 mmol) in 1,4-dioxane (52 mL) was stirred at 100° C. for 2 hours. The reaction mixture was then allowed to cool to room temperature, filtered through Celite®, rinsed with DCM, and concentrated to provide the title compound as an off-white solid.

1. filtrationfiltered through Celite®
2. washrinsed with DCM
3. concentrationconcentrated