HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 3-(chloromethyl)-5-nitro-1H-pyrazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | (3-nitro-1H-pyrazol-5-yl)methanol | HCID 135636628 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3-(chloromethyl)-5-nitro-1H-pyrazole | HCID 136175559 | — |
Reaction Steps
(5-Nitro-1H-pyrazol-3-yl)methanol (524 mg, 3.66 mmol) was first treated with SOCl2 (3 ml) in CH2Cl2 (5 ml) at 35° C. for 2 hrs. The solvent was removed to get a crude 3-(chloromethyl)-5-nitro-1H-pyrazole. Then following General Procedure A, the title compound (515 mg, 49%) was prepared from 2-amino-4-chlorobenzenethiol (161 mg, 1.01 mmol), crude 3-(chloromethyl)-5-nitro-1H-pyrazole, K2CO3 (468 mg, 3.39 mmol) in DMF (3 ml).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09328067B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-e3fe8d72bc9f46a2a29d25e9e6153b18 |
| Source note | uspto-grants-2016_05 |