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Potassium Carbonate → 5-chloro-2-(((5-nitro-1H-pyrazol-3-yl)methyl)thio)aniline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 2-Amino-4-chlorobenzenethiol | HCID 12000 | — |
| 反応物 | 3-(chloromethyl)-5-nitro-1H-pyrazole | HCID 136175559 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 5-chloro-2-(((5-nitro-1H-pyrazol-3-yl)methyl)thio)aniline | HCID 136372389 | 49% |
反応手順
(5-Nitro-1H-pyrazol-3-yl)methanol (524 mg, 3.66 mmol) was first treated with SOCl2 (3 ml) in CH2Cl2 (5 ml) at 35° C. for 2 hrs. The solvent was removed to get a crude 3-(chloromethyl)-5-nitro-1H-pyrazole. Then following General Procedure A, the title compound (515 mg, 49%) was prepared from 2-amino-4-chlorobenzenethiol (161 mg, 1.01 mmol), crude 3-(chloromethyl)-5-nitro-1H-pyrazole, K2CO3 (468 mg, 3.39 mmol) in DMF (3 ml).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09328067B2 |
| 出典データセット | uspto-grants-2016_05 |
| ORD ID | ord-47be77f2ffb1497b89e94a8071b67935 |
| 出典メモ | uspto-grants-2016_05 |