HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → 3-((2-amino-4-chlorophenyl)thio)-N,N-dimethylpropanamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | 2-Amino-4-chlorobenzenethiol | HCID 12000 | — |
| Reactant | N,N-Dimethylacrylamide | HCID 17587 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3-((2-amino-4-chlorophenyl)thio)-N,N-dimethylpropanamide | HCID 60961870 | 83% |
Reaction Steps
The solution of 2-amino-4-chlorobenzenethiol (824 mg, 5.126 mmol), N,N-dimethylacrylamide (512 mg, 5.162 mmol), and HOAc (1 ml) in CH2Cl2 (10 ml) was stirred at room temperature for 4 days. The solvent was removed and the residue was loaded on silica column and purified to yield a white solid (1.08 g, 83%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09328067B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-25823e8a5239419db1d9885b2fdf2364 |
| Source note | uspto-grants-2016_05 |