HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triphenylphosphine → 2-((2-(1H-pyrazol-4-yl)ethyl)thio)-5-chloroaniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | 2-Amino-4-chlorobenzenethiol | HCID 12000 | — |
| Reactant | 2-(1H-Pyrazol-4-yl)ethanol | HCID 4293604 | — |
| Reactant | Di-tert-butyl diazene-1,2-dicarboxylate | HCID 6034084 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-((2-(1H-pyrazol-4-yl)ethyl)thio)-5-chloroaniline | HCID 67972877 | — |
Reaction Steps
Following the General Procedure J, the title intermediate was prepared from 2-(1H-pyrazol-4-yl)ethanol (472 mg, 4.218 mmol), 2-amino-4-chlorobenzenethiol (1.01 g, 6.327 mmol), PPh3 (2.21 g, 8.436 mmol) and di-tert-butylazodicarboxylate (1.9 g, 8.436 mmol) in CH2Cl2 (20 ml).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09328067B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-46c1b1fe6b9d4ffa8f565f3892080706 |
| Source note | uspto-grants-2016_05 |