Methanol → HCID 57378524, compound

HRID 520898Notes

Reaction equation

HRID 520898 reaction equation
[BH4-].[Na+].[Cl:3][C:4]1[CH:9]=[CH:8][C:7]([S:10]([NH:13][C:14]2[CH:19]=[C:18]([Cl:20])[CH:17]=[CH:16][C:15]=2[S:21][CH:22]2[CH2:26][CH2:25][C:24](=[O:27])[CH2:23]2)(=[O:12])=[O:11])=[CH:6][C:5]=1[C:28]([F:31])([F:30])[F:29].C[OH:33]>>[Cl:3][C:4]1[CH:9]=[CH:8][C:7]([S:10]([NH:13][C:14]2[CH:19]=[C:18]([Cl:20])[CH:17]=[CH:16][C:15]=2[S:21]([CH:22]2[CH2:26][CH2:25][CH:24]([OH:27])[CH2:23]2)=[O:33])(=[O:12])=[O:11])=[CH:6][C:5]=1[C:28]([F:30])([F:29])[F:31]

Participants

4

Reactant 3

HCID 887MethanolHCID 4311764Sodium borohydrideHCID 679722914-Chloro-N-[5-chloro-2-(3-oxo-cyclopentylsulfanyl)-phenyl]-3-trifluoromethyl-benzenesulfonamide2×

Product 1

HCID 57378524HCID 57378524, compound

Procedure

Following General Procedure D, followed by treatment of the crude product with NaBH4 in MeOH, the title compound was prepared from 4-Chloro-N-[5-chloro-2-(3-oxo-cyclopentylsulfanyl)-phenyl]-3-trifluoromethyl-benzenesulfonamide (Intermediate 35).

Sources & evidence

ORD record
ord-cf9c38601369403194e8b837ced9843c
Source dataset
uspto-grants-2016_05
Patent number
US09328067B2

Reaction notes

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