3-Chloro-2-fluorobenzenesulfonyl Chloride → 3-chloro-N-[5-chloro-2-(methylthio)phenyl]-2-fluorobenzenesulfonamide

HRID 520923Notes

Reaction equation

HRID 520923 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([S:9][CH3:10])=[C:6]([NH2:8])[CH:7]=1.[Cl:11][C:12]1[C:13]([F:22])=[C:14]([S:18](Cl)(=[O:20])=[O:19])[CH:15]=[CH:16][CH:17]=1>>[Cl:11][C:12]1[C:13]([F:22])=[C:14]([S:18]([NH:8][C:6]2[CH:7]=[C:2]([Cl:1])[CH:3]=[CH:4][C:5]=2[S:9][CH3:10])(=[O:20])=[O:19])[CH:15]=[CH:16][CH:17]=1

Participants

3

Reactant 2

HCID 27783213-Chloro-2-fluorobenzenesulfonyl ChlorideHCID 27945775-Chloro-2-(methylthio)aniline

Product 1

HCID 573789973-chloro-N-[5-chloro-2-(methylthio)phenyl]-2-fluorobenzenesulfonamideYield 62%

Procedure

Following General Procedure B, the title compound (386 mg, 62%) was prepared from 5-chloro-2-methylsulfanyl-phenylamine (297 mg, 1.71 mmol) and 3-chloro-2-fluoro-benzenesulfonyl chloride (392 mg, 1.71 mmol).

Sources & evidence

ORD record
ord-83f15ab9e78643b0ab8a69992f055ae5
Source dataset
uspto-grants-2016_05
Patent number
US09328067B2

Reaction notes

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