HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Benzofuran-2-sulfonyl chloride → Methyl 2-[({2-[(1-benzofuran-2-ylsulfonyl)amino]-4-fluorophenyl}sulfanyl)methyl]benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Benzofuran-2-sulfonyl chloride | HCID 2795172 | — |
| Reactant | Methyl 2-(((2-amino-4-fluorophenyl)thio)methyl)benzoate | HCID 82976415 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | Methyl 2-[({2-[(1-benzofuran-2-ylsulfonyl)amino]-4-fluorophenyl}sulfanyl)methyl]benzoate | HCID 71714808 | 55% |
Reaction Steps
Following General Procedure B, the title compound (1.6 g, 55%) was prepared from methyl 2-(((2-amino-4-fluorophenyl)thio)methyl)benzoate (1.8 g, 6.19 mmol) and benzofuran-2-sulfonyl chloride (1.3 g, 6.19 mmol) in pyridine (10 ml).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09328067B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-ad5871abaff04808aef26320d0302ab1 |
| Source note | uspto-grants-2016_05 |