Chloroacetyl chloride → HCID 19962969, compound

HRID 52098Notes

Reaction equation

[N:1]1([CH2:7][C:8]2[CH:13]=[CH:12][N:11]=[C:10]([O:14][CH2:15][CH2:16][CH2:17][CH2:18][NH2:19])[CH:9]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[Cl:20][CH2:21][C:22](Cl)=[O:23]>>[N:1]1([CH2:7][C:8]2[CH:13]=[CH:12][N:11]=[C:10]([O:14][CH2:15][CH2:16][CH2:17][CH2:18][NH:19][C:22](=[O:23])[CH2:21][Cl:20])[CH:9]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

Reactant 2

HCID 6577Chloroacetyl chloride

HCID 150531254-(4-Piperidinomethyl-2-pyridyloxy)butylamine

Product 1

HCID 19962969HCID 19962969, compoundYield 80%

Procedure

Following a procedure similar to that described in Example 67(a), but using 4-(4-piperidinomethyl-2-pyridyloxy)butylamine and 2-chloroacetyl chloride as starting materials, in relative proportions similar to those used in that Example, the title compound was obtained as a white powder, melting at 59°-63° C., in an 80% yield.

Sources & evidence

ORD record: ord-7161fb576bfd421f82d606731e9b1555
Source dataset: uspto-grants-1997_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05616579

Reaction notes

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