Acetic Anhydride → HCID 19962941, compound

HRID 52099Notes

Reaction equation

HRID 52099 reaction equation
[N:1]1([CH2:7][C:8]2[CH:13]=[CH:12][N:11]=[C:10]([O:14][CH2:15][CH2:16][CH2:17][CH2:18][NH:19][C:20](=[O:26])[CH2:21][S:22][CH2:23][CH2:24][OH:25])[CH:9]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[C:27](OC(=O)C)(=[O:29])[CH3:28]>>[N:1]1([CH2:7][C:8]2[CH:13]=[CH:12][N:11]=[C:10]([O:14][CH2:15][CH2:16][CH2:17][CH2:18][NH:19][C:20](=[O:26])[CH2:21][S:22][CH2:23][CH2:24][O:25][C:27](=[O:29])[CH3:28])[CH:9]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 19962942N-[4-(4-piperidinomethyl-2-pyridyloxy)butyl]-2-(2-hydroxyethylthio)acetamide

Product 1

HCID 19962941HCID 19962941, compoundYield 84%

Procedure

Following a procedure similar to that described in Example 67(c), but using N-[4-(4-piperidinomethyl-2-pyridyloxy)butyl]-2-(2-hydroxyethylthio)acetamide [prepared as described in step (b) above] and acetic anhydride as starting materials, in relative proportions similar to those used in that Example, the title compound was obtained as an oil in an 84% yield.

Sources & evidence

ORD record
ord-c3f69ea2aefb42cc82b041bd74fce1f2
Source dataset
uspto-grants-1997_04
Patent number
US05616579

Reaction notes

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