HCID 86654089, compound → HCID 178487223, compound

HRID 521044Notes

Reaction equation

HRID 521044 reaction equation
[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]([OH:12])=O)=[CH:9][C:4]=2[N:3]=[CH:2]1.[CH3:13][O:14][C:15]1[CH:16]=[CH:17][C:18]2[CH2:27][CH2:26][C@H:25]3[C@H:20]([CH2:21][CH2:22][CH2:23][NH:24]3)[C:19]=2[CH:28]=1>>[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]([N:24]3[C@@H:25]4[C@@H:20]([C:19]5[CH:28]=[C:15]([O:14][CH3:13])[CH:16]=[CH:17][C:18]=5[CH2:27][CH2:26]4)[CH2:21][CH2:22][CH2:23]3)=[O:12])=[CH:9][C:4]=2[N:3]=[CH:2]1

Participants

3

Reactant 2

HCID 86654089HCID 86654089, compoundHCID 178524171HCID 178524171, compound

Product 1

HCID 178487223HCID 178487223, compoundYield 69%

Procedure

The title compound is prepared from 1H-benzoimidazole-5-carboxylic acid and cis-9-methoxy-1,2,3,4,4a,5,6,10b-octahydro-benzo[f]quinoline following a procedure analogous to that described in Example 1. Yield: 69% of theory; LC (method 1): tR=2.55 min; Mass spectrum (ESI+): m/z=362 [M+H]+.

Sources & evidence

ORD record
ord-0d9faf0135e44481b64de1d4674457f2
Source dataset
uspto-grants-2016_05
Patent number
US09328072B2

Reaction notes

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