HCID 86654072, compound → HCID 178487172, compound

HRID 521048Notes

Reaction equation

HRID 521048 reaction equation
[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]([OH:12])=O)=[CH:9][C:4]=2[N:3]=[CH:2]1.[CH3:13][O:14][C:15]1[CH:28]=[CH:27][C:18]2[C@@H:19]3[C@H:24]([CH2:25][CH2:26][C:17]=2[CH:16]=1)[NH:23][CH2:22][CH2:21][CH2:20]3>>[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]([N:23]3[C@@H:24]4[C@@H:19]([C:18]5[CH:27]=[CH:28][C:15]([O:14][CH3:13])=[CH:16][C:17]=5[CH2:26][CH2:25]4)[CH2:20][CH2:21][CH2:22]3)=[O:12])=[CH:9][C:4]=2[N:3]=[CH:2]1

Participants

3

Reactant 2

HCID 86654072HCID 86654072, compoundHCID 178524171HCID 178524171, compound

Product 1

HCID 178487172HCID 178487172, compoundYield 78%

Procedure

The title compound is prepared from 1H-benzoimidazole-5-carboxylic acid and cis-8-methoxy-1,2,3,4,4a,5,6,10b-octahydro-benzo[f]quinoline following a procedure analogous to that described in Example 1. Yield: 78% of theory; LC (method 1): tR=2.54 min; Mass spectrum (ESI+): m/z=362 [M+H]+.

Sources & evidence

ORD record
ord-98e808fdf45640328fe368289f9f26a8
Source dataset
uspto-grants-2016_05
Patent number
US09328072B2

Reaction notes

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