HCID 86654081, compound → HCID 178426739, compound

HRID 521111Notes

Reaction equation

HRID 521111 reaction equation
[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]([OH:12])=O)=[CH:9][C:4]=2[N:3]=[CH:2]1.[CH3:13][C:14]1[N:19]=[N:18][C:17]([O:20][C:21]2[C:26]3[C@@H:27]4[C@H:32]([CH2:33][CH2:34][C:25]=3[CH:24]=[CH:23][CH:22]=2)[NH:31][CH2:30][CH2:29][CH2:28]4)=[CH:16][CH:15]=1>>[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]([N:31]3[C@@H:32]4[C@@H:27]([C:26]5[C:21]([O:20][C:17]6[N:18]=[N:19][C:14]([CH3:13])=[CH:15][CH:16]=6)=[CH:22][CH:23]=[CH:24][C:25]=5[CH2:34][CH2:33]4)[CH2:28][CH2:29][CH2:30]3)=[O:12])=[CH:9][C:4]=2[N:3]=[CH:2]1

Participants

3

Reactant 2

HCID 86654081HCID 86654081, compoundHCID 178524171HCID 178524171, compound

Product 1

HCID 178426739HCID 178426739, compoundYield 17%

Procedure

The title compound is prepared from 1H-benzoimidazole-5-carboxylic acid and cis-10-(6-methyl-pyridazin-3-yloxy)-1,2,3,4,4a,5,6,10b-octahydro-benzo[f]quinoline following a procedure analogous to that described in Example 1. Yield: 17% of theory; LC (method 1): tR=2.39 min; Mass spectrum (ESI+): m/z=440 [M+H]+.

Sources & evidence

ORD record
ord-860853486d884d539bed56007905aaf9
Source dataset
uspto-grants-2016_05
Patent number
US09328072B2

Reaction notes

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