HCID 58294584, compound → HCID 178480021, compound

HRID 521167Notes

Reaction equation

HRID 521167 reaction equation
[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]([OH:12])=O)=[CH:9][C:4]=2[N:3]=[CH:2]1.[CH3:13][N:14]1[CH:18]=[C:17]([C:19]2[CH:20]=[CH:21][C:22]3[CH2:23][C@H:24]4[C@@H:29]([C:30]=3[CH:31]=2)[CH2:28][CH2:27][CH2:26][NH:25]4)[CH:16]=[N:15]1>>[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]([N:25]3[CH2:26][CH2:27][CH2:28][C@@H:29]4[C:30]5[CH:31]=[C:19]([C:17]6[CH:16]=[N:15][N:14]([CH3:13])[CH:18]=6)[CH:20]=[CH:21][C:22]=5[CH2:23][C@H:24]34)=[O:12])=[CH:9][C:4]=2[N:3]=[CH:2]1

Participants

3

Reactant 2

HCID 58294584HCID 58294584, compoundHCID 178524171HCID 178524171, compound

Product 1

HCID 178480021HCID 178480021, compoundYield 78%

Procedure

The title compound is prepared from 1H-benzoimidazole-5-carboxylic acid and cis-6-(1-methyl-1H-pyrazol-4-yl)-2,3,4,4a,9,9a-hexahydro-1H-indeno[2,1-b]pyridine following a procedure analogous to that described in Example 1. Yield: 78% of theory; LC (method 1): tR=2.35 min; Mass spectrum (ESI+): m/z=398 [M+H]+.

Sources & evidence

ORD record
ord-941e5f62bf3f4d0b874083acaafecb55
Source dataset
uspto-grants-2016_05
Patent number
US09328072B2

Reaction notes

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