Potassium Phosphate, Tribasic → HCID 86729376, compound

Participants

Reaction Conditions

Reaction Steps

2-(5-Bromopyridin-2-yl)propan-2-ol (Intermediate 5) (23 mg, 0.11 mmol), 2,2,2-trifluoroethyl 4-(3-amino-4-carbamoyl-1H-pyrazol-1-yl)-4-(cyanomethyl)piperidine-1-carboxylate (Intermediate 35-3) 40 mg, 0.11 mmol), Pd2(dba)3 (10 mg, 0.011 mmol), 2-di-t-butylphosphino-3,4,5,6-teramethyl-2′,4′,6′-triisopropylbiphenyl (15 mg, 0.032 mmol), potassium phosphate (45 mg, 0.21 mmol), and 1,4-dioxane (1.0 mL) were combined in a 4 mL vial. The vial was capped and flushed with argon. The mixture was heated to 90° C. and allowed to stir for 2 hours. The mixture was then cooled to ambient temperature, diluted with EtOAc, and washed sequentially with water and brine. The organic layer was dried over anhydrous MgSO4, filtered, and concentrated in vacuo. The residue was purified by MPLC on silica gel (using a gradient elution of 0-10% MeOH/DCM) to afford the title compound, Example #10-1.

Provenance & Evidence