Lithium borohydride → HCID 86729408, compound

Participants

Reaction Steps

To a solution of 1-methoxy-2-methyl-1-oxopropan-2-yl 4-{4-carbamoyl-3-[(4-fluorophenyl)amino]-1H-pyrazol-1-yl}-4-(cyanomethyl)piperidine-1-carboxylate (70 mg, 0.14 mmol) in THF (1.9 mL) at ambient temperature was added LiBH4 (25 mg, 1.2 mmol). The mixture was allowed to stir at ambient temperature for 3 hours. The mixture was then diluted with EtOAc and saturated aqueous ammonium chloride. The organic layer was separated, washed with water, brine, dried over anhydrous MgSO4, filtered, and concentrated in vacuo. The residue was purified by MPLC on silica gel (using a gradient elution of 0-10% MeOH/EtOAc) to afford the title compound, Example 29.

Provenance & Evidence