HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → [3-(2-Methyl-[1,3]dioxolan-2-yl)propyl](3-nitro-quinolin-4-yl)amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 3-(2-Methyl-1,3-dioxolan-2-yl)-1-propanamine | HCID 560007 | — |
| Reactant | 4-Chloro-3-nitroquinoline | HCID 11275808 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | [3-(2-Methyl-[1,3]dioxolan-2-yl)propyl](3-nitro-quinolin-4-yl)amine | HCID 69506985 | 64.3% |
Reaction Steps
The general method described in Step 1 of Example 1 was used to react 4-chloro-3-nitroquinoline (45.0 g, 216 mmol), 3-(2-methyl-[1,3]dioxolan-2-yl)propylamine (37.0 g, 255 mmol, prepared as described in PCT Publication WO 01/51486) and triethylamine (37.0 g, 366 mmol) in dichloromethane for 15 hours to provide [3-(2-methyl-[1,3]dioxolan-2-yl)propyl]-(3-nitroquinolin-4-yl)amine (44.1 g) as a yellow solid after recrystallization from a toluene/hexane mixture.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09328110B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-fef2844cc9fa4e24b100a4b47e1bbb4c |
| Source note | uspto-grants-2016_05 |