反应详情

1.0 g of N-[4-(4-piperidinomethyl-2-pyridyloxy)-cis-2-butenyl]-3-(acetylthio)propionamide [prepared as described in step (a) above] and 0.49 g of a 28% w/v methanolic solution of sodium methoxide were added to 20 ml of methanol, whilst ice-cooling, and the mixture was stirred at the same temperature for 20 minutes. At the end of this time, 0.15 ml of acetic acid was added, and the solvent was removed by distillation under reduced pressure. The residue was dissolved in ethyl acetate, washed with water and condensed by evaporation under reduced pressure, to obtain 0.76 g (yield 85%) of the title compound as an oil.

1. temperaturecooling
2. customthe solvent was removed by distillation under reduced pressure
3. dissolutionThe residue was dissolved in ethyl acetate
4. washwashed with water and condensed by evaporation under reduced pressure