反应详情

温度

65 °C

To the solution of 2-bromo-5-fluoro-3-nitrobenzoic acid (35 g) in MeOH (400 mL) was added SOCl2 (40 mL) drop-wise at 10-15° C. The reaction was then stirred at 65° C. for 1 h. After cooling to room temperature, the solvent was evaporated in vacuum to afford a residue, which was chromatographed on silica gel using gradient eluant of 0-100% EtOAc in hexane to provide methyl 2-bromo-5-fluoro-3-nitrobenzoate (20 g, 84%).

1. temperatureAfter cooling to room temperature
2. customthe solvent was evaporated in vacuum
3. customto afford a residue, which
4. customwas chromatographed on silica gel using gradient eluant of 0-100% EtOAc in hexane