Hydrochloric Acid → HCID 178479661, compound

Participants

Reaction Steps

To a solution of tert-butyl 3-oxo-7,8,10,11-tetrahydro-2H-phthalazino[8,1-bc][1,7]naphthyridine-9(3H)-carboxylate (100 mg) in dioxane (6 mL) was added con.HCl (2.0 mL) dropwise, the mixture was then stirred at room temperature for 0.5 h. The solvent was evaporated in vacuo and water (10 mL) was added. The mixture was washed with methylene dichloride (20 mL), and the aqueous phase was evaporated to afford 8,9,10,11-tetrahydro-2H-phthalazino[8,1-bc][1,7]naphthyridin-3(7H)-one hydrochloride (46 mg, 57%). 1H NMR (DMSO-d6) δ 11.9 (s, 1H), 10.95 (s, 1H), 9.59 (s, 1H), 7.34-7.69 (m, 3H), 3.33-3.51 (m, 4H), 2.55-2.56 (m, 2H). MS (ESI) m/e [M+1]+241.0.

Provenance & Evidence